Desmethylselegiline | ||||||
---|---|---|---|---|---|---|
CYP Content | Km | Vmax | Vmax/Km | Hepatic Clearance | Hepatic Clearance | |
pmol/mg | μM | pmol/pmol/min | ml/μmolP450*min | l/h | % of total | |
1A1 | 1-b | 161 | 7 | 43 | 0 | 1-b |
1A2 | 50 | 334 | 12 | 36 | 7 | 6 |
2A6 | 66 | 376 | 5 | 13 | 3 | 3 |
2B6 | 26 | 25 | 52 | 2055 | 62 | 57 |
2C81-a | 1-b | 82 | 3 | 37 | 1-b | 1-b |
2C9 | 55 | 628 | 3 | 5 | 1 | 1 |
2C19 | 26 | 20 | 7 | 350 | 26 | 24 |
2D6 | 11 | 1-c | 1-c | 1-c | 1-c | 1-c |
2E1 | 53 | 678 | 7 | 10 | 2 | 2 |
3A41-a | 127 | 608 | 10 | 16 | 8 | 7 |
Levomethamphetamine | ||||||
---|---|---|---|---|---|---|
CYP Content | Km | Vmax | Vmax/Km | Hepatic Clearance | Hepatic Clearance | |
pmol/mg | μM | pmol/pmol/min | ml/μmolP450*min | l/h | % of total | |
1A1 | 1-b | 117 | 10 | 85 | 0 | 1-b |
1A2 | 50 | 379 | 32 | 84 | 14 | 9 |
2A6 | 66 | 1-c | 1-c | 1-c | 1-c | 1-c |
2B6 | 26 | 33 | 65 | 1994 | 62 | 40 |
2C81-a | 1-b | 630 | 7 | 11 | 0 | 1-b |
2C9 | 55 | 252 | 2 | 8 | 2 | 0 |
2C19 | 26 | 20 | 30 | 1500 | 56 | 36 |
2D6 | 11 | 1-c | 1-c | 1-c | 1-c | 1-c |
2E1 | 53 | 437 | 6 | 14 | 3 | 2 |
3A41-a | 127 | 612 | 28 | 46 | 19 | 12 |
The subsequent calculation of hepatic clearance uses the conversion factors described under Materials and Methods. The contribution of each specific enzyme to the hepatic clearance is also shown. The data for the specific P450 content were from GENTEST (http://www.gentest.com/prod_inserts/H161_2.htm#immunoquantitation).