Inhibition of selegiline metabolite formation in human liver microsomes using mouse monoclonal inhibitory antibodies against human CYP2B6
| Liver | Substrate Conc. | % Inhibition by CYP2B6 Antiserum | |
|---|---|---|---|
| Levomethamphetamine | Desmethylselegiline | ||
| μM | |||
| HL33 | 25 | 43.2 | 40.2 |
| HL33 | 100 | 18.2 | 19.5 |
| HL44 | 25 | 25.1 | 7.4 |
| HL44 | 100 | 23.0 | 20.4 |
| HL41 | 25 | 2.3 | −28.6 |