Table 1

Allelic frequencies of PXR protein variants in Caucasians and Africans

Variant^1-a	Effect	WT Sequence^1-b (5′-3′)	Mutation Sequence^1-b(5′-3′)	Caucasians		Africans
Variant^1-a	Effect	WT Sequence^1-b (5′-3′)	Mutation Sequence^1-b(5′-3′)	N	%	N	%
Exon 2
c.52G>A	E18K	`ACTGTGAGGAC`	`ACTGTAAGGAC`	300	0.0	74	1.4
c.79C>T	P27S	`GAAAGCCCAGT`	`GAAAGTCCAGT`	300	0.0	74	14.9
c.106G>A	G36R	`AAGTCGGAGGT`	`AAGTCGGAGGT`	300	3.0	74	0.0
Exon 4
c.418G>A	V140M	`TGGGAGTGCAG`	`TGGGAATGCAG`	418	0.2	74	0.0
c.488A>G	D163G	`CTTTGACACTA`	`CTTTGGCACTA`	418	0.0	74	1.4
Exon 8
c.1108G>A	A370T	`AATTCGCCATT`	`AATTCACCATT`	312	0.0	64	1.6

WT, wild-type; N, number of chromosomes analyzed.
↵1-a The nomenclature of the variants is based on Antonarakis and the Nomenclature Working Group (1998). As the translation initiation site, the CTG with the C at position 280 of the cDNA (GI 3769538) is numbered +1. The nucleotide 5′ to +1 is numbered −1.
↵1-b The variant position is indicated in bold.