Table 7

Patients' cysteine levels in the plasma before any infusion, immediately after the first amifostine infusion, and immediately after the first mesna infusion

	Total Reducible Cysteine (μM)	% Thiol
Patient 1
Before	162	30
After amifostine	131	66
After mesna	80	69
Patient 2
Before	123	41
After amifostine	114	>95
After mesna	81	78
Patient 5
Before	41	0
After mesna	59	20
Patient 6
Before	94	1
After mesna	57	5

Patients 1 and 2 received amifostine (825 mg/m² i.v. over 15 min) followed by mesna (400 mg/m² i.v. over 15 min). Patient 5 received only mesna (750 mg/m²), as an i.v. push. Patient 6 received only mesna (360 mg/m²), as an i.v. over 30 min. The percentage of thiol was calculated from the ratio of the value measured for cysteine to the value for total reducible cysteine.