Total Reducible Cysteine (μM) | % Thiol | |
---|---|---|
Patient 1 | ||
Before | 162 | 30 |
After amifostine | 131 | 66 |
After mesna | 80 | 69 |
Patient 2 | ||
Before | 123 | 41 |
After amifostine | 114 | >95 |
After mesna | 81 | 78 |
Patient 5 | ||
Before | 41 | 0 |
After mesna | 59 | 20 |
Patient 6 | ||
Before | 94 | 1 |
After mesna | 57 | 5 |
Patients 1 and 2 received amifostine (825 mg/m2 i.v. over 15 min) followed by mesna (400 mg/m2 i.v. over 15 min). Patient 5 received only mesna (750 mg/m2), as an i.v. push. Patient 6 received only mesna (360 mg/m2), as an i.v. over 30 min. The percentage of thiol was calculated from the ratio of the value measured for cysteine to the value for total reducible cysteine.