Table 8

Levels of WR-1065 and mesna in the PBMC and plasma immediately following amifostine and mesna infusions, respectively in patients 3 and 4

	WR-1065		Mesna
	PBMC	Plasma	PBMC	Plasma
	μM
Patient 3 (ifosfamide course)	37^8-a	44^8-a	108	270
Patient 4 (cyclophosphamide course)	67^8-b	93^8-b	62	410

Blood samples (1.0 ml each) were collected after the completion of each drug infusion. The plasma and purified PBMC were prepared and analyzed as described under Materials and Methods.

↵8-a The amifostine infusion lasted 43 min, instead of 15 min, due to hypotension.
↵8-b The sample was drawn 3 min after the end of amifostine infusion.