Table 1

Summary of pharmacokinetic parameters of compound I in rats and dogs

Species	Intravenous
Species	Dose CompoundI	CL_p	V_dss	t_1/2	AUC
		ml/min/kg	l/kg	min	μM · h
Dog	2 mg/kg	10.6 ± 0.36	0.50 ± 0.03	34.4 ± 2.6	7.77 ± 0.26
	5 mg/kg	15.3 ± 3.6	0.67 ± 0.17	37 ± 10	14.1 ± 3.7
	10 mg/kg	11.8 ± 3.1	0.59 ± 0.06	33 ± 8	37.3 ± 12.3
Rat	5 mg/kg	41.2 ± 2.03	1.18 ± 0.25	40.9 ± 8.6	5.02 ± 0.25

	Oral
	Dose CompoundI	C_max	T_max	AUC	F
		μM	min	μM · h	%
Dog	10 mg/kg	22.8 ± 2.46	33.3 ± 11.6	39.9 ± 11.7	∼100
Rat	10 mg/kg	7.36 ± 4.29	16.0 ± 5.5	4.53 ± 2.59	45

Data represents mean ± S.D. of n = 3 rats and dogs.