Metabolite | Rat | Dog | ||||||
---|---|---|---|---|---|---|---|---|
Retention Time | Urine | Bile | Total | Urine | Bile | Wash | Total | |
min | ||||||||
M1 | 4.1 | 9.5 | 10.7 | 20.1 | 16.1 | 0.4 | 2.0 | 18.5 |
M2 | 5.1 | 15.9 | 15.9 | 6.9 | 5.0 | 0.4 | 12.4 | |
M3 | 5.7 | 3.1 | 10.4 | 23.4 | 3.4 | 2.5 | 29.3 | |
M4 | 7.4 | 7.3 | 0.3 | 0.3 | 0.3 | 0.3 | ||
M7 | 12.8 | 0.1 | 0.1 | 0.4 | 0.6 | 0.6 | ||
M8 | 13.9 | 0.3 | 1.5 | 11.3 | 2.7 | 0.2 | 2.9 | |
M9 | 16.5 | 9.8 | 3.7 | 3.7 | 7.9 | 0.4 | 8.3 | |
M15 | 22.3 | 21.0 | 21.0 | 0.1 | 0.2 | 0.3 | ||
M16 | 25.1 | 7.9 | 7.9 | 1.0 | 1.0 | |||
M17 | 28.9 | 9.7 | 9.7 | 0.1 | 1.0 | 1.1 | ||
M18 | 29.2 | 0.2 | 1.6 | 1.8 | ||||
M19 | 29.8 | 0.2 | 0.2 | 0.4 | 0.9 | 0.9 | ||
CompoundI | 30.7 | 0.2 | 1.2 | 1.4 | 0.5 | 1.0 | 1.5 | |
SUM | 27.4 | 75.2 | 102.6 | 50.9 | 22.4 | 4.9 | 78.2 |
Shown as mean of n = 3 for rats and dogs. Profiles were determined using pooled samples from individual animals using urine and bile that was collected 72 h postdose; data represented as percentage of dose.