Table 1

Apparent kinetic parameters for the N-glucuronides of S(−)- and R(⁺)-nicotine in human liver microsomes

Substrate	K_m	V_max	V_max/K_m
	mM	pmol/min/mg	μl/min/mg
S(−)-Nicotine	0.11 ± 0.017	132 ± 4.5	1.2 ± 0.27
R(⁺)-Nicotine	0.23 ± 0.028	69.9 ± 2.2	0.31 ± 0.08