Mean (±S.E.M.) canalicular membrane enzyme activities and plasma liver function test results in rats administered vehicle only or 15 mg/kg diclofenac daily for 7 days
| Control | Diclofenac | |
|---|---|---|
| n = 6 | ||
| Canalicular enzyme activities | ||
| Mg2+-ATPase (μmol/h/mg protein) | 70.0 ± 13.2 | 27.7 ± 5.42-150 |
| γ-Glutamyltransferase (μmol/h/mg protein) | 11.7 ± 2.0 | 6.1 ± 1.12-150 |
| Leucine aminopeptidase (μmol/h/mg protein) | 10.6 ± 3.0 | 5.1 ± 1.52-150 |
| Alkaline phosphatase (μmol/h/mg protein) | 12.4 ± 2.4 | 34.9 ± 14.6 |
| Plasma liver function tests | ||
| Albumin (g/l) | 34.2 ± 0.5 | 27.8 ± 1.42-150 |
| Total bilirubin (μmol/l) | 1.6 ± 1.4 | 3.2 ± 1.6 |
| Alkaline phosphatase (U/l) | 355 ± 33 | 217 ± 212-150 |
| Aspartate transaminase (U/l) | 92 ± 8 | 76 ± 14 |
| γ-Glutamyltransferase (U/l) | 2.2 ± 1.0 | 3.5 ± 1.0 |
| Alanine transaminase (U/l) | 56 ± 5 | 35 ± 52-150 |
↵2-150 p < 0.05 compared with control (Mann-Whitney U test).