Deuterated Analog | Deuterium Isotope Effect | |
---|---|---|
CJ-12,458 Formation | CJ-12,764 Formation | |
CYP3A4 | ||
[d 1]Ezlopitant | 1.26 ± 0.13 | 1.43 ± 0.10 |
[d 3]Ezlopitant | 1.07 ± 0.11 | 0.87 ± 0.07 |
[d 4]Ezlopitant | 1.06 ± 0.09 | 0.84 ± 0.04 |
[d 6]Ezlopitant | 1.12 ± 0.13 | 0.84 ± 0.07 |
[d 7]Ezlopitant | 1.55 ± 0.17 | 1.25 ± 0.09 |
CYP2D6 | ||
[d 1]Ezlopitant | 2.21 ± 0.11 | 1.74 ± 0.13 |
[d 3]Ezlopitant | 1.08 ± 0.08 | 0.85 ± 0.07 |
[d 4]Ezlopitant | 1.07 ± 0.08 | 0.78 ± 0.04 |
[d 6]Ezlopitant | 1.12 ± 0.06 | 0.90 ± 0.05 |
[d 7]Ezlopitant | 2.61 ± 0.34 | 1.48 ± 0.10 |
Each value represents the mean ± S.D. of n = 6 determinations.