Deuterated Analog | Ratio of Benzyl Alcohol to Alkene | |
---|---|---|
CYP3A4 | CYP2D6 | |
[d 0]Ezlopitant | 1.08 ± 0.04 | 1.27 ± 0.03 |
[d 1]Ezlopitant | 0.94 ± 0.01 | 1.62 ± 0.16 |
[d 3]Ezlopitant | 1.32 ± 0.03 | 1.63 ± 0.11 |
[d 4]Ezlopitant | 1.36 ± 0.03 | 1.75 ± 0.04 |
[d 6]Ezlopitant | 1.43 ± 0.05 | 1.58 ± 0.05 |
[d 7]Ezlopitant | 1.34 ± 0.01 | 2.12 ± 0.09 |
Each value represents the mean ± S.D. of n = 6 determinations.