Table 2

Mean partial AUC values for rofecoxib and 5-hydroxyrofecoxib in rat plasma following intravenous (2 mg/kg) or oral (5 mg/kg) administration of [4-¹⁴C]rofecoxib or [4-¹⁴C]5-hydroxyrofecoxib to intact and bile duct-cannulated rats

Compound Dosed	Dose/Route	Model	Interval	Partial AUC^2-a
				Rofecoxib		5-Hydroxyrofecoxib
				Mean	S.D.	Mean	S.D.
			h	ng · h/ml
Rofecoxib	2 /i.v.	Intact	0–24	2367	351	675	95.8
	2 /i.v.	Cannulated	0–10	1966	173	120^2-b	9.61^2-b
	5 /p.o.	Intact	0–24	7965	1901	905	69.2
	5 /p.o.	Cannulated	0–10	6385	2749	314	51.6
5-Hydroxyrofecoxib	2 /i.v.	Intact	0–24	1042	79.9	184	101
	2 /i.v.	Cannulated	0–24	1255	334	25.3^2-c	17.6^2-c
	5 /p.o.	Intact	0–24	1018	155	376	171
	5 /p.o.	Cannulated	0–10	514	109	37.2^2-b	13^2-b

↵2-a Values represent the mean and S.D.; n = 4. For bile duct-cannulated rats dosed with [4-¹⁴C]5-hydroxyrofecoxib, n = 3.
↵2-b The mean AUC is a partial value from 0 to 6 h.
↵2-c The mean AUC is a partial value from 0 to 2 h.