Effect of delavirdine on kinetic parameters for diclofenac 4′-hydroxylation by human liver microsomes
| Delavirdine | KM | Vmax | Ki | α |
|---|---|---|---|---|
| μM | μM | nmol/min/mg | μM | |
| 0 | 4.5 ± 0.5 | 4.2 ± 0.1 | ||
| 3 | 10 ± 2 | 3.8 ± 0.3 | Not applicable | Not applicable |
| 10 | 12 ± 3 | 2.4 ± 0.2 | ||
| 30 | 15 ± 4 | 1.3 ± 0.2 | ||
| 100 | 21 ± 6 | 0.54 ± 0.08 | ||
| Combined2-a | 4.7 ± 0.4 | 4.3 ± 0.1 | 2.6 ± 0.4 | 6.1 ± 1.8 |
Values shown ± S.E. of parameter estimate.
↵2-a Estimated by fitting data to eq.3.