Metabolism of HAL, HTP, RH, and RHP+ by 12 human liver microsomal preparations
| Microsomes | Substrates | |||||||
|---|---|---|---|---|---|---|---|---|
| HAL | HTP | RH | RHP+ | |||||
| CPHP | HP+ | CPTP | HP+ | CPHP | HAL | RHP+ | HP+ | |
| HLM003 | 25.3 | 22.8 | 5.0 | 1.93 | 25.3 | 274 | 0.101 | 1.29 |
| HLM006 | 20.0 | 13.1 | 3.8 | 1.53 | 20.0 | 286 | 0.023 | 0.95 |
| HLM023 | 17.8 | 13.4 | 0.0 | 1.23 | 17.8 | 282 | 0.046 | 0.90 |
| HLM030 | 47.6 | 34.5 | 6.1 | 2.93 | 47.6 | 270 | 0.277 | 1.87 |
| HLM042 | 84.9 | 87.1 | 13.7 | 6.46 | 84.9 | 180 | 0.455 | 4.55 |
| HLM043 | 16.1 | 16.5 | 0.0 | 2.32 | 16.1 | 291 | 0.022 | 1.18 |
| HLM056 | 19.1 | 19.5 | 3.0 | 2.26 | 19.1 | 305 | 0.055 | 1.38 |
| HLM066 | 30.1 | 30.3 | 6.7 | 3.70 | 30.1 | 279 | 0.103 | 1.68 |
| HLM070 | 43.8 | 40.5 | 7.3 | 4.48 | 43.8 | 254 | 0.117 | 2.16 |
| HLM089 | 55.8 | 49.9 | 9.0 | 5.89 | 55.8 | 230 | 0.269 | 2.86 |
| HLM093 | 13.3 | 8.2 | 3.6 | 1.51 | 13.3 | 287 | 0.000 | 1.37 |
| HLM112 | 109.0 | 104.3 | 24.0 | 12.47 | 109.0 | 153 | 0.286 | 6.49 |
| Mean | 40.2 | 36.7 | 6.9 | 3.89 | 40.2 | 258 | 0.146 | 2.22 |
| S.E.M. | 8.7 | 8.8 | 1.9 | 0.92 | 8.7 | 14 | 0.041 | 0.49 |
Data are from one duplicate experiment and are presented as picomoles per milligram of protein per minute.