Table 3

Correlation coefficients (r) relating catalytic activities of P450 isoform-selective substrate to HAL metabolite formation by a bank of 12 human liver microsomes

Isoenzymes	Substrate
	HAL		HTP		RH		RHP⁺
	CPHP	HP⁺	CPTP	HP⁺	CPHP	HAL	RHP⁺	HP⁺
CYP1A2	0.10	0.16	0.20	0.20	0.10	0.26	0.13	0.19
CYP2C8	0.42	0.39	0.33	0.20	0.42	0.32	0.61^3-a	0.28
CYP2C9	0.29	0.18	0.26	0.22	0.29	0.12	0.23	0.19
CYP2C19	0.33	0.31	0.31	0.47	0.33	0.24	0.08	0.39
CYP2D	0.27	0.20	0.26	0.28	0.27	0.23	0.18	0.23
CYP2E	0.23	0.23	0.38	0.26	0.23	0.24	0.09	0.29
CYP3A	0.97^3-b	0.96^3-b	0.92^3-b	0.93^3-b	0.97^3-b	0.92^3-b	0.87^3-b	0.93^3-b

Data on the activities of the isoenzymes were supplied by GENTEST. The selective substrates used for each isoenzyme are listed underExperimental Procedures.

↵3-a P < 0.05.
↵3-b P < 0.01.