Comparison of IC50 values obtained using the cocktail and individual probe substrates
| Individual Probe IC50 | Cocktail IC50 | |
|---|---|---|
| μM | ||
| Ketoconazole | ||
| CYP3A4 | 0.1 | 0.1 |
| CYP2D6 | 33 | 20 |
| CYP2C9 | 29 | 20 |
| CYP1A2 | 22 | 30 |
| CYP2C19 | 27 | 26 |
| CYP2A6 | >50 | >50 |
| CYP2C8 | 9 | 6 |
| Quinidine | ||
| CYP3A4 | 28 | 36 |
| CYP2D6 | <0.1 | <0.1 |
| CYP2C9 | >50 | >50 |
| CYP1A2 | >50 | 50 |
| CYP2C19 | >50 | 50 |
| CYP2A6 | >50 | >50 |
| CYP2C8 | 50 | 50 |
| Sulfaphenazole | ||
| CYP3A4 | >50 | >50 |
| CYP2D6 | >50 | >50 |
| CYP2C9 | 1 | 1 |
| CYP1A2 | >50 | >50 |
| CYP2C19 | >50 | >50 |
| CYP2A6 | >50 | >50 |
| CYP2C8 | >50 | >50 |
| Tranylcypromine | ||
| CYP3A4 | >50 | >50 |
| CYP2D6 | 41 | 50 |
| CYP2C9 | 38 | 41 |
| CYP1A2 | >50 | 45 |
| CYP2C19 | 9 | 8 |
| CYP2A6 | 0.6 | 0.3 |
| CYP2C8 | 35 | 26 |
| Quercetin | ||
| CYP3A4 | >50 | >50 |
| CYP2D6 | >50 | >50 |
| CYP2C9 | 42 | 15 |
| CYP1A2 | 9 | 8 |
| CYP2C19 | >50 | >50 |
| CYP2A6 | >50 | >50 |
| CYP2C8 | 7 | 7 |