Liver | DM FNTZ Formation | 3-OH FNTZ Formation | ||||||
---|---|---|---|---|---|---|---|---|
Vmax1-a | Km1-b | A1-c | Vmax/Km1-d | Vmax1-a | Km1-b | A1-c | Vmax/Km1-d | |
HLM1 | 308.7 | 148.8 | 1.25 | 2.08 | 1611.3 | 225.4 | 2.00 | 7.15 |
HLM2 | 307.2 | 288.0 | 1.22 | 1.07 | 1532.9 | 241.4 | 1.79 | 6.35 |
HLM3 | 371.7 | 222.9 | 1.13 | 1.67 | 3633.2 | 280.7 | 1.44 | 12.94 |
HLM4 | 927.8 | 170.8 | 1.20 | 5.43 | 7910.2 | 279.5 | 1.57 | 28.30 |
Mean1-e | 478.9 | 207.6 | 1.20 | 2.56 | 3671.9 | 256.8 | 1.70 | 13.69 |
S.E.1-f | 150.4 | 31.0 | 0.03 | 0.98 | 1494.0 | 13.9 | 0.12 | 5.09 |
HLM, human liver microsomes.
↵1-a Vmax in units of pmol min−1 (mg protein)−1.
↵1-b Km in units of μM.
↵1-c A, Hill coefficient.
↵1-d Vmax/Km, approximate intrinsic clearance, in units of μl min−1 (mg protein)−1.
↵1-e Mean, arithmetic mean of four different human livers (HLM1–4).
↵1-f S.E., standard error of four different human livers (HLM1–4).