Table 2

Relative rates of DM FNTZ formation by cDNA-expressed CYPs and CYP2C19 Supersomes

CYPRelative Rate/pmol CYP2-a
95 μM FNTZ950 μM FNTZ
VectorN.D.DM FNTZ formation detected2-b
1A2N.D.0.11
2A60.110.20
2B60.200.29
2C8N.D.0.66
2C90.470.27
2C190.810.70
2C19 (Supersomes)0.870.55
2D6N.D.0.13
2E1N.D.N.D.
3A41.001.00

  • N.D., no DM FNTZ detected.

  • ↵2-a  Relative rate/pmol CYP = normalized to rate of CYP3A4.

  • ↵2-b  DM FNTZ formation detected, metabolite formation rate could not be determined since vector CYP protein content is minimal and amounts are not available.