Table 1

Percentage of disappearance of substrates following a 60-min incubation with hepatic microsomal fractions in the presence and absence of 1% methanol (245 mM)

Compound	No Solvent	1% MeOH (245 mM)
LAQ094	3^1-a	73^1-a
Metaraminol	15^1-b	85^1-b
(−)-Isoproterenol	24^1-b	66^1-b

↵1-a Determined by UV absorbance.
↵1-b Determined by LC/MS/MS method, mean of two duplicate experiments.