Table 1
Kinetic rate constants for metabolism of XN in rat liver microsomes
Substrate
V
max
K
m
V
max
/
K
m
R
2
nmol/min/nmol P450
μM
M1
0.0072 ± 0.0005
20.16 ± 8.81
0.0004
0.98
M2
0.0911 ± 0.0077
118.97 ± 38.66
0.0008
0.99
M3
0.0035 ± 0.0006
246 ± 116.39
0.00001
0.97
XN
1.46 ± 0.119
407.36 ± 79.48
0.004
0.99