Effects of treatments of male rats with chemical inducers on liver microsomal 1,8-cineole 2-hydroxylation activities
| Treatment of Rats | P450 Content | 1,8-Cineole 2-Hydroxylation |
|---|---|---|
| nmol/mg protein | nmol/min/nmol P450 | |
| Untreated | 0.67 | <0.05 |
| β-Naphthoflavone | 1.16 | <0.05 |
| Isosafrole | 1.10 | <0.05 |
| Phenobarbital | 1.48 | 1.6 ± 0.04 |
| Ethanol | 0.96 | <0.05 |
| PCN | 1.41 | 10.4 ± 0.17 |
1,8-Cineole 2-hydroxylation activities by liver microsomes of rats treated with various chemicals were determined by the methods as described under Materials and Methods. Data are means of duplicate determinations.