Table 2

Average CYP2C mRNA induction ratios in response to dexamethasone, rifampicin, and phenobarbital in human hepatocyte cultures

Inducers^2-a	CYP2C8	CYP2C9	CYP2C18	CYP2C19
Dexamethasone	2.9 ± 0.6^2-150	3.5 ± 1.8^2-150	1.0 ± 0.4	1.5 ± 0.6
	(2.2–3.3)	(1.5–6.2)	(0.6–1.5)	(1.0–2.3)
Rifampicin	5.5 ± 2.9^2-150	3.3 ± 1.5^2-150	1.0 ± 0.2	1.8 ± 0.7
	(1.5–8.5)	(1.8–5.0)	(0.8–1.2)	(1.0–2.7)
Phenobarbital	3.2 ± 1.5^2-150	3.0 ± 0.9^2-150	1.1 ± 0.4	2.1 ± 0.6
	(2–6)	(2.2–4.2)	(0.8–1.6)	(1.5–2.7)

Data from cultures FT137, FT138, FT145, FT150, and FT151. Numbers in parentheses refer to the extreme values of the induction ratio.

↵2-150 Significantly different from 1.0 (level in untreated cells), P < 0.05, using the paired t test.
↵2-a Inducer concentration: 10 μM for dexamethasone and rifampicin and 100 μM for phenobarbital; duration of treatment: 72 h.