Pharmacokinetic parameters of doxorubicin conjugate following i.v. administration to mice, rats, dogs, and monkeys
| Species | Dose | Plasma Clearance | Distribution Volume | Terminal t 1/2 | Fraction Metabolized to Doxorubicin |
|---|---|---|---|---|---|
| mg/kg | ml/min/kg | l/kg | h | % | |
| Mice | 20 | 9 | 0.2 | 0.9 | 32 |
| Rats | 20 | 24 ± 5 | 0.2 ± 0 | 0.2 ± 0.1 | 28 |
| Dogs | 6 | 14 | 0.4 | 0.8 | 41 |
| Monkeys | 6 | 36 | 0.7 | 0.3 | 36 |
Results are shown as mean or mean ± S.D. of two to three animals. In mice, pharmacokinetic parameters were calculated using pooled mean concentrations obtained from three animals per time point.