Relative distribution of 3H radioactivity among different mouse body organs (mean ± S.D., n = 3)2-a
| Tissue | Sampling Time (Minutes) | |||||
|---|---|---|---|---|---|---|
| 2 | 5 | 10 | 30 | 60 | 120 | |
| % | ||||||
| Blood | 6.8 ± 0.73 | 5.79 ± 1.56 | 5.28 ± 0.46 | 3.44 ± 0.60 | 2.56 ± 0.75 | 1.22 ± 0.34 |
| Liver | 22.39 ± 4.66 | 20.65 ± 4.86 | 18.10 ± 2.27 | 11.49 ± 0.73 | 7.44 ± 1.57 | 3.63 ± 0.61 |
| Kidney | 6.31 ± 0.60 | 5.97 ± 2.11 | 3.62 ± 1.00 | 2.39 ± 1.00 | 0.98 ± 0.18 | 0.50 ± 0.03 |
| Proximal gut | 2.96 ± 0.79 | 6.76 ± 0.63 | 11.49 ± 4.37 | 7.47 ± 2.70 | 2.52 ± 1.09 | 2.36 ± 0.76 |
| Gut | 8.47 ± 0.70 | 11.20 ± 0.44 | 16.23 ± 1.25 | 24.76 ± 1.67 | 38.55 ± 0.54 | 33.80 ± 2.06 |
| Bladder | 0.22 ± 0.15 | 3.92 ± 1.73 | 11.09 ± 1.07 | 19.39 ± 2.95 | 22.89 ± 6.09 | 28.93 ± 7.64 |
↵2-a Radioactivity contents in individual organs were established by liquid scintillation measurements and expressed as percentages of the total administered dose—intravenous injection of 74 kBq of [3H]bohemine/g of body weight (see Experimental Procedures).