Table 4

logD7.0 and Ki values of various HMG-CoA reductase inhibitors for the inhibition of mexazolam metabolism by female human liver microsomes

InhibitorlogD7.0Kivalue
LactoneAcidLactoneAcid
μM
Pravastatin2.42−0.47115  ± 9No inhibition
Simvastatin4.401.882.13  ± 0.1469.6  ± 5.2
Lovastatin3.911.512.98  ± 0.18179  ± 18
Fluvastatin3.651.757.10  ± 0.39289  ± 44
Atorvastatin4.21.532.54  ± 0.12189  ± 30
Cerivastatin5.22.322.18  ± 0.1046.3  ± 2.1

Ki values (mean ± calculated S.D.) were calculated from data shown in Fig. 6 according to eq. 4.