Substrate | Conc. range | P450 | Product Formed | Internal Standard | Assay | Reference |
---|---|---|---|---|---|---|
μM | ||||||
Estrone | 6.25–400 | CYP1A2 | 2-OH-Estrone | BA t-5,6-diol | HPLC | Shou et al., 1997 |
Phenacetin | 3.9–250 | CYP1A2 | Acetaminophen | Temazepam | LC-MS | See text |
Ethoxyresorufin | 0.05–50 | CYP1A2 | Resorufin | External standard | Fluorescence | See text |
Diazepam | 1–500 | CYP2B6 | Nordiazepam | BA t-5,6-D | HPLC | Yang et al., 1998 |
Paclitaxel | 1.6–200 | CYP2C8 | 6α-OH-Paclitaxel | Bacctin | HPLC | Rahman et al., 1994 |
Flurbiprofen | 15.6–1000 | CYP2C9 | 4′-OH-Flurbiprofen | BA t-5,6-D | HPLC | Tracy et al., 1995 |
Celecoxib | 0.5–30 | CYP2C9 | Hydroxycelecoxib | Diclofenac | HPLC | Tang et al., 2000 |
CYP2C9*2 | ||||||
CYP2C9*3 | ||||||
(S)-Mephenytoin | 1.56–150 | CYP2C19 | 4′-OH-M | Nirvanol | HPLC | Goldstein et al., 1994 |
Dextromethorphan | 3.0–2000 | CYP2D6 | Dextrorphan | BA t-5,6-diol | HPLC | See text |
Chlorzoxazone | 2–1000 | CYP2E1 | 6-OH-C | BA t-5,6-diol | HPLC | Peter et al., 1990 |
Testosterone | 6.26–1250 | CYP3A4 | 6β-OH-T | 6β-OH-Progesterone | HPLC | Hanioka et al., 1990 |
Progesterone | 2.5–500 | CYP3A4 | 6β-OH-P | Estradiol | HPLC | See text |
Benzyloxyresorufin | 2.5–50 | CYP3A4 | Resorufin | External standard | Fluorescence | See text |
6-OH-C, 6-OH-chlorzoxazone; 6β-OH-T, 6β-OH-testosterone; 6β-OH-P, 6β-OH-progesterone; BA t-5,6-D, BAt-5,6-diol; LC-MS, liquid chromatography-mass spectrometry.