Table 1

Pharmacokinetic parameters following a single 60-mg intravenous or 120-mg oral dose of [14C]nateglinide in male subjects

ParameterIntravenous DoseOral Dose
Plasma NateglinidePlasma RadioactivityBlood RadioactivityPlasma NateglinidePlasma RadioactivityBlood Radioactivity
C max (ng or ngEq/ml)1-a 5,6906,3603,760
AUC0–∞ (ng or ngEq · h/ml)8,15012,0006,17011,80020,30011,100
t 1/2, λabs(h)0.200.180.19
t 1/2, λ1(h)0.220.330.290.781.81.9
t 1/2, λ2(h)1.52.41.91.95135
t 1/2, λ3(h)3619
  • 1-a  Not applicable.