Table 3

Plasma concentrations in human after a single dose of [14C]nateglinide3-a

Peak3-b
TimeM11M12M1M2, M3M7NateglinideM4, M5, M6
Oral 120-mg Dose
h ngEq/ml
1.042.436.023785.312127800
2.068.650.724288.610419500
4.088.055.117069.363.953310.8
6.032.828.747.623.126.11634.4
8.015.513.519.29.615.690.02.7
12.04.15.04.62.15.726.20
Intravenous 60-mg Dose
ngEq/ml
1.044.836.722886.511117600
2.032.230.810436.243.84380
4.030.118.749.221.526.72200
  • 3-a  Pool of subjects 1 to 6 at the time points indicated. Recovery of total plasma radioactivity after acetonitrile extraction was complete (∼100%).

  • 3-b  Chemical structures are shown in Fig. 1.