Table 1

Summary of AQ4N in vivo pharmacokinetic data following i.v. administration of AQ4N at 20, 100, and 200 mg/kg

Dose (mg/kg)
20100200
C max (μg/ml)99.5 ± 22.5505.5 ± 168.51172 ± 84
t 1/2(terminal) (h)0.830.720.64
AUC0–∞ (μg/h/ml)14.183.5246.7
Clearance (1 h/kg)1.421.190.81