Pharmacokinetic data summary for AQ4N and the metabolites AQ4M and AQ4 following i.v. administration of AQ4N at 20, 100, and 200 mg/kg
| Dose (mg/kg) | |||
|---|---|---|---|
| 20 | 100 | 200 | |
| C max (μg/ml) | |||
| AQ4 | 0.3 | 1.0 ± 1.08 | 3.71 ± 4.81 |
| AQ4M | 6.49 ± 2.49 | 85.14 ± 78.66 | 80.77 ± 58.1 |
| AQ4N | 99.5 ± 22.5 | 505.5 ± 168.5 | 1172 ± 84 |
| AUC0–∞ (μg/h/ml) | |||
| AQ4 | 0.07 | 0.34 | 3.54 |
| AQ4M | 1.15 | 8.43 | 44.10 |
| AQ4N | 14.1 | 83.5 | 246.7 |