Table 2

Effect of P450 isoform inhibitors on the metabolism of DDB in human liver microsomes

InhibitorInhibitor ConcentrationPercentage of Control Activity
M1M2M3M4M5
μM
Furafylline0100100100100100
1093.9113.133.928.62-a
5095.671.111.816.5
Sulfaphenazole0100100100100100
1095.5106.398.8100.367.5
10046.953.253.2102.358.9
Diethyldithiocarbamate0100100100100100
1012192.583.9100.497.1
5090.495.479.084.789.1
Quinidine0100100100100100
10104.398.8100.2100.397.4
5087.7100.585.590.889.9
Ketoconazole0100100100100100
175.592.584.791.785.5
526.434.255.387.936.6
1016.717.333.378.216.3
Troleandomycin0100100100100100
20769399
100628471
200478252

Each value represents the mean of two determinations.

  • 2-a —, not determined due to the overlapping with inhibitor-oriented peaks.