Table 1

Elimination of radioactivity following single oral and intravenous doses of [14C]gemifloxacin mesylate

SamplePercentage of Dose Eliminated
RatDog
Oral (168 mg fb/kg)1-aIntravenous (10 mg fb/kg)1-aOral (24 mg fb/kg)1-aIntravenous (10 mg fb/kg)1-b
Urine
 0–24 h8.7  ± 2.245.2  ± 1.76.7  ± 1.324.2  ± 3.9
 0–96 h8.9  ± 2.146.1  ± 1.89.6  ± 2.326.5  ± 4.3
Bile
 0–24 h4.4  ± 1.512.3  ± 1.36.9  ± 2.628.1  ± 2.0
 0–96 h4.5  ± 1.812.5  ± 1.38.4  ± 3.230.0  ± 2.5
Feces
 0–24 h85.3  ± 3.430.8  ± 1.538.8  ± 6.021.3  ± 14.6
 0–96 h89.0  ± 3.333.2  ± 1.475.6  ± 3.138.6  ± 6.7
Total recovery1-c
 0–96 h103  ± 1.194.8  ± 1.395.2  ± 1.796.5  ± 0.5

Data are mean values ± S.D.

  • ↵1-a  N = 3.

  • ↵1-b  N = 4.

  • ↵1-c  Total recovery includes radioactivity recovered in cage washings, G.I. tracts, and carcasses in the rat and cage washings and cage debris in the dog.