Table 4

Radiometabolite patterns in the plasma of rats and dogs following oral administration of [14C]gemifloxacin mesylate

CompoundPercentage of Plasma Radioactivity
Rat (168 mg fb/kg)Dog (24 mg fb/kg)
1 h2 h6 h2 h6 h12 h
Gemifloxacin68.368.754.263.364.355.2
Gemifloxacin acyl glucuronide4.63.93.03.83.62.2
E-Isomer of gemifloxacin10.07.112.25.18.89.0
N-Acetyl gemifloxacin2.43.13.2N.D.N.D.N.D.
Hydroxymethyl gemifloxacin1.34.95.41.71.10.9
Gemifloxacin glutamateN.D.N.D.N.D.2.42.63.7

Radiometabolite patterns were determined in plasma samples pooled from three animals at each time point.

  • N.D., not detected.