Radiometabolite patterns in the plasma of rats and dogs following oral administration of [14C]gemifloxacin mesylate
| Compound | Percentage of Plasma Radioactivity | |||||
|---|---|---|---|---|---|---|
| Rat (168 mg fb/kg) | Dog (24 mg fb/kg) | |||||
| 1 h | 2 h | 6 h | 2 h | 6 h | 12 h | |
| Gemifloxacin | 68.3 | 68.7 | 54.2 | 63.3 | 64.3 | 55.2 |
| Gemifloxacin acyl glucuronide | 4.6 | 3.9 | 3.0 | 3.8 | 3.6 | 2.2 |
| E-Isomer of gemifloxacin | 10.0 | 7.1 | 12.2 | 5.1 | 8.8 | 9.0 |
| N-Acetyl gemifloxacin | 2.4 | 3.1 | 3.2 | N.D. | N.D. | N.D. |
| Hydroxymethyl gemifloxacin | 1.3 | 4.9 | 5.4 | 1.7 | 1.1 | 0.9 |
| Gemifloxacin glutamate | N.D. | N.D. | N.D. | 2.4 | 2.6 | 3.7 |
Radiometabolite patterns were determined in plasma samples pooled from three animals at each time point.
N.D., not detected.