Table 1

Na+ dependence in the uptake of MX-68, MTX, and TCA by isolated rat hepatocytes 1-a

ControlNa+-Free
MX-68100  ± 5.689.4  ± 4.2
MTX100  ± 3.252.7  ± 5.41-b
Taurocholate100  ± 3.228.3  ± 3.61-b
  • 1-a The initial uptake velocity of the substrate at 1 μM was determined by subtracting the uptake at 30 s from that at 90 s. All values were normalized by the uptake in the presence of Na+ as 100%. Data represent the mean ± S.E. of three determinations in three preparations.

  • 1-b Significantly different from control (p < 0.05).