Table 6

Pharmacokinetic parameters of midazolam and erythromycin

MidazolamErythromycin
Dose, substrate9.69 μmol6-a Dose, inhibitor681 μmol6-a
fb,s 0.056-a fb,i 0.78
Km,s 3.7 μM6-b fh,i 0.53
Vmax,s(0) 2410 μmol/hr6-b Fa 16-c
Vd,s 20.2 liter6-a ka 3.42 h−1
Kp,s 13.2Km,i 88 μM6-d
Vmax,i(0) 1960 μmol/h6-d
Vd,i 46.2 liter6-e
Kp,i 29.7
kdeg 0.0578 h−1
kinact 0.0655 min−1
Ki 81.8 μM
  • 6-a  Olkkola et al. (1993).

  • 6-b  Wandel et al. (1998).

  • 6-c  Assumed that Fais 1 to avoid false negative prediction since Fa is unknown.

  • 6-d  Wang et al. (1997).

  • 6-e  Kroboth et al. (1982).