Table 1

Pharmacokinetic parameters of cimetidine, itraconazole, and erythromycin in humans

Tmaxkelt1/2kaReference
h h−1 h h−1
Cimetidine1.00.33  ± 0.022.02  ± 0.35 Walkenstein et al. (1978)
1.01.5  ± 0.31.38 Grahnen et al. (1979)
1.00.50  ± 2.230.57  ± 2.68 Kelly et al. (1995)
Itraconazole3.0  ± 0.70.0375  ± 0.012020.7  ± 9.31.23 Hardin et al. (1988)
4.5  ± 1.120.6  ± 5.40.712 Barone et al. (1993)
4.4  ± 0.927.9  ± 9.90.819 Oguchi et al. (1991)
Erythromycin6.00.2043.40.134 Kroboth et al. (1982)
4.00.2772.50.225 Malmborg (1979)
4.00.3651.90.162 Schreiner and Digranes (1984)
  • Values are means ± S.D.