Table 3

Predicted plasma and liver concentrations of cimetidine, itraconazole, and erythromycin in humans

kaDoseCsysCpf3-aCHf3-aCportal,maxCpf3-bCHf3-b
min−1 mg μM
CIM0.022180010.08.015.556.245.087.2
ITZ0.01532000.710.002410.02823.570.01210.153
EM0.002895003.452.6956.04.753.7077.0

  • ↵3-a  Calculated from systemic plasma concentration.

  • ↵3-b  Calculated from maximal portal plasma concentration.