Cimetidine | Erythromycin | Itraconazole | ||||
---|---|---|---|---|---|---|
− | + | − | + | − | + | |
CLH(ml/min/kg) | 7.354-a | 5.844-a | 7.84-b | 3.64-b | 8.74-c | 2.74-c |
1.26 | 2.2 | 3.2 | ||||
Fpred | ||||||
Prediction 14-d | 1.021 | 1.017 | 1.006 | |||
Prediction 24-e | 1.043 | 1.26 | 1.066 | |||
Prediction 34-f | 1.12 | 1.019 | 1.029 | |||
Prediction 44-g | 1.23 | 1.41 | 1.37 | |||
Prediction 54-h | —4-i | 2.6 | — |
Fobs, observed F value;Fpred, predicted F value.
↵4-a Klotz et al., 1985.
↵4-b Olkkola et al., 1993.
↵4-c Olkkola et al., 1996.
↵4-d Prediction using unbound plasma concentration of inhibitors calculated from systemic plasma concentration.
↵4-e Prediction using unbound liver concentration of inhibitors calculated from systemic plasma concentration.
↵4-f Prediction using unbound plasma concentration of inhibitors calculated from maximal portal plasma concentration.
↵4-g Prediction using unbound liver concentration of inhibitors calculated from maximal portal plasma concentration.
↵4-h Prediction by physiological model based on mechanism-based inhibition.
↵4-i —, not determined.