Table 1

Effect of furafylline on the metabolism of MeIQx and PhIP

In vitro N-hydroxylation by human liver microsomal fraction1-a
 MeIQx control76.6  ± 21.1
 MeIQx +furafylline6.5  ± 5.3
 PhIP control55.5  ± 15.6
 PhIP + furafylline0.85  ± 0.9
Excretion of unchanged amine in human urine1-b
 MeIQx (placebo)2.2  ± 1.1
 MeIQx (furafylline)31.3  ± 14.8
 PhIP (placebo)1.2  ± 0.7
 PhIP (furafylline)4.2  ± 2.1

  • ↵1-a Values are mean ± S.D. (n = 4) pmol of N-hydroxy HA min−1 mg of microsomal protein−1.

  • ↵1-b Values are mean ± S.D. (n = 6) percent of the ingested dose excreted as unchanged amine.