Table 3

PhIP-induced mutation in hamster XEMh1A2 cells (hprt) in vitro, and in MutaMouse (lacZ) in vivo

MutationPercentage of Mutations
hprt (Hamster)lacZ (Mouse)
Base substitutions
 GC→TA6442
 GC→AT1517
 GC→CG54
 AT→?08
Frameshifts
 −1 G:C base pair12.521
+1 G:C base pair00
 −1 A:T base pair00
+1 A:T base pair00
 Complex mutation2.58