Table 1
cDNA-ExpressedLiver Sample
CYP2C19CYP3A4K-27K-12K-25K-29
Desmethylflunitrazepam Formation
 High Affinity
  V max(nmol/mg/min)0.0950.0440.0520.1200.082
  K m(μM)11.121476238
  V max/K m × 103 8.562.101.111.942.16
 Low Affinity
  V max(nmol/mg/min)1.270.1020.3070.1850.089
  K m(μM)10894314141112
  V max/K m × 103 11.761.090.981.310.79
3-Hydroxyflunitrazepam Formation
 High Affinity
  V max(nmol/mg/min)0.4200.1160.1350.1520.108
  K m(μM)34.0641138188
  V max/K m × 103 12.351.811.191.881.23
 Low Affinity
  V max(nmol/mg/min)0.8610.3910.6810.4260.344
  K m(μM)642186391305277
  V max/K m × 103 1.340.941.741.401.24