Table 4

Allele frequencies of HFE mutations reported in sizable surveys in various normal populations

845A (C282Y)187G (H63D)PopulationNumber of Chromosomes Studied4-aReference
0.06100.136Caucasian US (New Mexico)574 Garry et al., 1997
0.0750.158Caucasian US (California)386 Beutler et al., 1996
0.0660.150Caucasian US (Maine)2004 Bradley et al., 1998
0.09440.169French508 Jézéquel et al., 1998
0.0380.136Europe (all)2900 Merryweather-Clarke et al., 1997
0.0130.097Ashkenazi Jews762 Beutler and Gelbart, 1997
0.0130.135Greeks392 Merryweather-Clarke et al., 1997
0.00.01Japanese504 Sohda et al., 1999
0.00.029Southeast Asia274 Rochette et al., 1999

Note that frequencies refer to allele and not heterozygote frequencies.

  • 4-a  Number of individuals studied = ½ (number of chromosomes).