Table 2

N-Oxidation of trimethylamine in fish malodor patients, heterozygotes (carriers), and unaffected individuals following a normal diet and a 600-mg trimethylamine oral challenge dose

GroupFollowing a Normal Diet
Free Trimethylamine as a Percentage of Total ExcretionTrimethylamine/ N-Oxide Ratio
Fish malodor
 Males = 478.5  ± 13.3 (59–89)3.65
 Females = 971.8  ± 15.7 (46–90)2.55
Heterozygotes (n = 13)4.5  ± 1.8 (2–8)0.047
Unaffected controls (n = 75)4.3  ± 2.5 (2–9)0.045
GroupFollowing a 600-mg Challenge Dose
Free Trimethylamine as a Percentage of Total ExcretionTrimethylamine/ N-Oxide Ratio
Fish malodor
 Males = 491.5  ± 5.1 (84–95)10.76
 Females = 685.8  ± 7.1 (77–93)6.04
Heterozygotes (n = 13)24.5  ± 2.7 (21–29)0.32
Unaffected controls (n = 75)6.6  ± 3.0 (1–13)0.071

Results are expressed as the mean ± S.D. Ranges are given in parentheses.