Table 7

In vivo estimation of apparent Vmax and Km of VPA glucuronidation in adult sheep and 10-day-old lambs via modeling of urine data

ParameterAdult7-a(n = 5)10-day-old7-a(n = 17)
V max(μg/min/kg)288.5 (5)326.5 (8)
K m(μg/ml)30.0 (17)68.2 (17)
  • 7-a  Estimates presented as the parameter estimate followed by the CV in parentheses.