Mean tissue concentrations of 4-[14C]cholesterol-AmBisome-derived radioactivity in Sprague-Dawley rats after intravenous administration of 3 mg/kg AmBisome (2.8 mg/kg cholesterol)
| Tissue | Time (h) | |||||||
|---|---|---|---|---|---|---|---|---|
| 3 | 8 | 12 | 24 | 48 | 72 | 96 | 168 | |
| μg-Eq/g | ||||||||
| Adipose | 1.1 | 0.8 | 0.6 | 0.7 | 0.6 | 1.0 | 0.7 | 0.6 |
| Eyes | 0.4 | 0.5 | 0.4 | 0.5 | 0.6 | 0.6 | 0.4 | 0.4 |
| Heart | 4.4 | 3.6 | 3.5 | 3.4 | 3.2 | 2.6 | 2.1 | 1.5 |
| Small intestine | 2.0 | 4.7 | 6.1 | 9.6 | 10.0 | 11.9 | 7.3 | 5.2 |
| Kidney | 3.5 | 3.1 | 2.7 | 3.1 | 2.6 | 2.7 | 2.7 | 2.4 |
| Liver | 20.7 | 17.1 | 13.5 | 9.9 | 6.2 | 4.9 | 3.0 | 2.0 |
| Lung | 6.9 | 9.7 | 10.0 | 9.5 | 8.2 | 6.7 | 4.9 | 4.1 |
| Plasma | 33.9 | 16.3 | 8.0 | 3.1 | 1.6 | 1.0 | 0.7 | 0.5 |
| Skeletal muscle | 0.3 | 0.5 | 0.5 | 0.7 | 0.7 | 0.8 | 0.7 | 0.6 |
| Skin | 0.5 | 0.8 | 0.9 | 1.2 | 1.3 | 1.4 | 1.4 | 1.0 |
| Spleen | 21.0 | 19.4 | 18.4 | 16.0 | 9.5 | 5.7 | 4.7 | 3.0 |
| Residual carcass | 0.9 | 1.1 | 1.2 | 1.3 | 1.2 | 1.2 | 0.9 | 0.8 |
N = 6 (3/sex/group) except at 3 h whereN = 5 (2 males) and 96 h where N = 10 (5/sex/group).