Table 1
Response elements in the 5′-flanking region of the CYP3A23 gene
| Sequence | Site | Nuclear Receptor | Reference |
|---|---|---|---|
TGAACT tca TGAACT
| Fp1 | PXR, COUP-TF | Quattrochi et al., 1995 |
| Site-B | Huss et al., 1996 | ||
| DexRE-2 | Huss and Kasper, 1998 | ||
| DR-3 | Miyata et al., 1995 | ||
| 6βA-B (CYP3A2) | |||
←——
TTAACT caaagg AGGTCA
| Site-C | Unknown: candidates are PXR, COUP-TF | Huss and Kasper, 1998 |
| DexRE-1 | Miyata et al., 1995 | ||
| 6βA-C (CYP3A2) | |||
| GTACCAAAGTCCAC | Site-A | HNF-4 | Huss and Kasper, 1998 |
| GTACCAAAGTCCAG | 6βA-A | Huss et al., 1999 | |
| (CYP3A2) | |||
| Miyata et al., 1995 | |||
| CACGTG | Site-A | USF-1 | Huss et al., 1999 |
| GGCACA gca TGTTAT | Footprint I (GRE) | GR | Pereira et al., 1998 |
Sequence and nomenclature of binding sites for the PXR and other nuclear receptors are given for CYP3A23 and CYP3A2 where noted.