Table 4

Correlation coefficients (r values obtained by linear regression analysis of nine samples) for formation rates for almokalant metabolites by human liver microsomes and the content and activities of individual forms of P450

Metabolite	Apoprotein Content
Metabolite	CYP 1A1	CYP 1A2	CYP 2A6	CYP 2C8	CYP 2C9	CYP 2C19	CYP 2D6	CYP 2E1	CYP 3A4	CYP 3A5	CYP 4A11
M3	0.47	0.06	0.12	0.24	0.21	0.16	0.20	0.56	0.76	0.27	0.06
M13	0.50	0.50	0.09	0.26	0.05	0.46	0.05	0.23	0.56	0.01	0.39
M16	0.45	0.18	0.15	0.20	0.12	0.24	0.15	0.47	0.78	0.25	0.06

	Monooxygenase Activities
	CYP 1A2	CYP 2A6	CYP 2C9	CYP 2C19	CYP 2D6	CYP 2E1	CYP 3A4	12-OH LA	11-OH LA
M3	0.08	0.24	0.30	0.32	0.31	0.11	0.90	0.36	0.48
M13	0.52	0.16	0.12	0.68	0.58	0.07	0.66	0.57	0.43
M16	0.19	0.23	0.20	0.42	0.40	0.04	0.88	0.43	0.46

11/12-OH LA, lauric acid 11/12-hydroxylase.