Summary of statistical analysis of concentrations of nicotine, cotinine, and nornicotine in brain and blood across 1 to 21 days of continuous peripheral [2′-14C]nicotine administration
| Continuous Administration | |
|---|---|
| Overall ANOVA for concentration | Compound × biological sample × duration of infusion interaction (F (8.28) = 12.91,p < 0.001) |
| ANOVA of nicotine concentration | Duration of infusion × biological sample interaction (F (1.14) = 19.26, p < 0.001) |
| ANOVA of cotinine concentration | Duration of infusion × biological sample interaction (F (4.14) = 5.78,p < 0.01) |
| ANOVA of nornicotine concentration | Duration of infusion × biological sample interaction (F (4.14) = 4.09, p < 0.05) |
| Overall ANOVA for brain/blood ratio | Main effect of compound (F (2.28) = 3.68, p < 0.05): main effect of duration of infusion (F (4.14) = 4.19,p < 0.05) |