Comparison of the IC50 values
| Compound | IC50 Ratios in HLM with Various Substrates | IC50 Ratios in HLM with Various Substrates/Supersomes | ||||
|---|---|---|---|---|---|---|
| Midaz/Dext | Testos/Dext | Testos/Midaz | Dext/Supersomes | Midaz/Supersomes | Testos/Supersomes | |
| Ketoconazole | 0.3 | 0.1 | 0.3 | 5.6 | 1.4 | 0.6 |
| 3 | 2.5 | 2.1 | 0.8 | 0.5 | 1.4 | 1.1 |
| 4 | 2.3 | 2.7 | 1.2 | 0.8 | 1.8 | 2.2 |
| 5 | 7.3 | 6.6 | 0.9 | 0.8 | 5.6 | 5.0 |
| 10 | 4.4 | 6.0 | 1.4 | 4.8 | 20.4 | 28.6 |
| 15 | 2.6 | 4.7 | 1.9 | 0.4 | 1.1 | 2.0 |
| 18 | 3.4 | 1.3 | 0.4 | 7.7 | 26.3 | 100.0 |
| 22 | 2.8 | 1.2 | 0.4 | 4.8 | 13.2 | 5.9 |
| 23 | 2.7 | 3.0 | 1.1 | 6.3 | 16.9 | 18.5 |
| 25 | 3.7 | 5.2 | 1.4 | 11.5 | 41.7 | 58.8 |
| 26 | 10.0 | 1.9 | 0.2 | 5.3 | 52.6 | 10.0 |
| 28 | 1.3 | 0.8 | 0.7 | 25.6 | 32.3 | 20.8 |
| 39 | 4.3 | 2.6 | 0.6 | 5.0 | 21.3 | 13.0 |
| 44 | 1.6 | 1.0 | 0.6 | 40 | 66.7 | 41.7 |
| 45 | 2.1 | 0.3 | 0.1 | 18.9 | 38.5 | 5.3 |
| 52 | 1.8 | 0.3 | 0.2 | 3.8 | 6.7 | 1.2 |
| Number of matches4-150 | 13 | 12 | 14 | 8 | 3 | 5 |
| Percentage of matches4-150 | 87 | 80 | 93 | 53 | 20 | 33 |
Midaz, midazolam; Dext, dextromethorphan; Testos, testosterone.
↵4-150  Ketoconazole was not included.