Table 1

Plasma exposure of amprenavir and nelfinavir after multiple doses

CmaxAUC0→∞AUC0→6 hAUC6→24 h
μg/ml h·μg/ml
Amprenavir (450 mg/kg/day)
 Day 111.0  ± 0.5120.5  ± 10.534.7  ± 5.682.4  ± 5.4
 Day 147.4  ± 1.01-150 59.5  ± 9.41-150,1-aa13.0  ± 2.21-150 46.5  ± 9.81-150
Nelfinavir (175 mg/kg/day)
 Day 15.4  ± 0.4
 Day 142.6  ± 0.31-150

Rats were dosed twice daily with the total daily dose being evenly divided among the two dosing regimens. For nelfinavir, blood samples were collected 1 h after the second dose of the day to measure the anticipated Cmax. Values represent mean ± S.E. (n = 3–4)

  • ↵1-150 p < 0.05

  • ↵1-a AUC0→24 h.